The first written mention of Sezemice is from 1227, when Kojata IV Hrabišic bequeathed the village to the Cistercian Sedlec Abbey.

However, the convent was destroyed during the Hussite Wars in 1421 and Sezemice was acquired by Diviš Bořek of Miletínek.

[4] In 1488, Sezemice was bought by Jan Anděl of Ronov and was first referred to as a market town.

[4] During the Thirty Years' War, Sezemice was burned down by the army of General Lennart Torstensson.

Other trials for the market town were the Seven Years' War and epidemics of plague and cholera.