His grandfather Mirza Ghiyas Beg and father Abu'l-Hasan Asaf Khan were the wazirs of the Mughal emperors Jahangir and Shah Jahan, respectively.
He also developed a reputation as a successful military commander and grew close to his nephew, the prince Aurangzeb, when the duo fought against the kingdom of Golconda.
[9] However, the territory was also fiercely contested by Maratha ruler, Shivaji who had acquired a reputation after his killing of Adilshahi general, Afzal Khan in 1659.
According to a tale, the Nawab lost three fingers while running from Shivray while his son was killed in an encounter with the Marathas in the palace courtyard.
[14] Taking advantage of the confusion and darkness, the Marathas escaped the palace and Pune, despite the widespread camping of Mughal forces.
Shaista Khan encouraged the construction of modern townships and public works in Dhaka, leading to a massive urban and economic expansion.
He was a patron of the arts and encouraged the construction of majestic monuments across the province, including mosques, mausoleums and palaces that represented the finest in Indo-Sarcenic and Mughal architecture.
Khan greatly expanded Lalbagh Fort, Chowk Bazaar Mosque, Saat Masjid and Choto Katra.
[18] The previous Siege of Hooghly by Shaishta Khan were considered by Saugata Bhaduri, professor from Jawaharlal Nehru University, as an attempt by the empire to threaten the Portuguese settlers in Bengal to assist them in conquest of Chittagong.
The Portuguese, led by Captain Moor, set fire to Arakanese fleets and fled to Bhulua where Thanadar Farhad Khan gave them refuge.
Ibn Hussain, Shaista Khan's admiral, was asked to lead the navy, while the subahdar himself took up the responsibility of supplying provisions for the campaign.
His legacy was the expansion of Dhaka into a regional centre of trade, politics and culture; a thriving and prosperous city from a small township.
Incorporating unique elements of Bengali and Mughal architecture, it is a major tourist attraction and a valued historical monument protected by the Government of Bangladesh today.