Shake Me Up is the tenth studio album by the American rock band Little Feat, released in 1991 (see 1991 in music).

It is also their only album to feature no lead vocals from keyboardist Bill Payne.

Among the album's contributors were Bonnie Bramlett (now Sheridan) who had last featured with the group on Dixie Chicken in 1973 and Valerie Carter who had worked closely with the group's founder Lowell George in his latter years.

Another backing vocalist, Shaun Murphy, got to sing lead on a line of Spider's Blues (Might Need It Sometime).

Murphy would join the group in Craig Fuller's place after he left in 1993.