In March 2002, Mystikal was sued by Steve Winn, the creator of the Cajun in Your Pocket keychain toy, who claimed that "Shake Ya Ass" bore many similarities to his product.

[1] In an interview with RapGenius, Mystikal explained that he was reluctant to release the song as a single at first, stating that he felt that it did not adequately showcase his abilities as an artist.

As he enters the house, he notices a group of bikini-clad women wearing masks and shaking on the dance floor.

It has been featured in the films The Hot Chick, Zoolander, Crossroads, Down to Earth, Juwanna Mann, Scary Movie 2, Identity Thief, About a Boy and It's a Boy Girl Thing and the HBO television series Treme and in the first-season episode "Everybody Hates Drew" of TV series Everybody Hates Chris.

In 2019, the song lyrics were read by former WCW commentator Tony Schiavone on his popular podcast What Happened When.