"Shake the Disease" is a song by English electronic music band Depeche Mode, released as a single on 29 April 1985.

"[2] The music video is the first Depeche Mode video directed by Peter Care, and features a camera trick that makes the band members appear to slowly tip over.

[3][4] It was shot in the Docklands area of London, prominently featuring the cranes that were still in situ at that time.

[9] The track also reached number 33 on the Hot Dance/Disco 12 Inch Singles Sales chart in the United States.

[11] AllMusic reviewer Dave Thompson praised the song, saying, "with its plump melody and stirring refrain, it's a haunting and soulful number that deserved better than its #18 chart position.