[10][11][3][9][8] In 2001, she transitioned to television journalism, becoming the evening and late-night news reporter for WBTV in Charlotte, North Carolina.

[12] While at WRC-TV, Bream met Brit Hume, who was the managing editor of Fox News's Washington, D.C. bureau.

[13] On August 11, 2022, it was announced that Bream would replace Chris Wallace as Fox News Sunday's new anchor, beginning September 11, 2022.

In addition to hosting Fox News Sunday, Bream appears periodically on other Fox News programs, including America's Newsroom, Outnumbered, America Reports, The Story with Martha MacCallum, The Five, Special Report and Gutfeld!

Bream is the author of three books: Finding the Bright Side: The Art of Chasing What Matters,[14] The Women of the Bible Speak: The Wisdom of 16 Women and Their Lessons for Today,[15] and The Mothers and Daughters of the Bible Speak: Lessons on Faith from Nine Biblical Families.