Subsequently, Ikeazor became the Vice President for Business Development and Government Relations for the United States firm Good Works International (GWI) Consulting, from 2003 to 2008.

She was the principal consultant for General Electric (GE) on the National Integrated Power Project (NIPP) with the Federal Government of Nigeria.

[12] She has carried on the philanthropy work of her late father, Chimezie Ikeazor (SAN), founder of the Non-Governmental Organization (NGO), Free Legal Aid for the Poor in Nigeria.

Similarly, she runs a prison outreach program that pays the fines of those awaiting trial as well as providing free legal representation for some of the inmates.

[8][13] She founded The Wakiliyan Mata Empowerment Initiative, an NGO for Internally Displaced Women, which avails them of interest-free loans to start small scale businesses.

[16] Ikeazor served as the Executive Secretary of PTAD from 2016 to 2019, during which she was tasked with steering the organization towards its mandate of sustainable welfare fulfillment for pensioners.

Ikeazor was sworn in as Minister of State for Environment of the Muhammadu Buhari-led administration, following a successful screening exercise conducted by the National Assembly.