Sharpe Homestead and Cemetery is a historic home and cemetery located at Defreestville in Rensselaer County, New York.

The house was built about 1740 and is a 1+1⁄2-story rectangular frame dwelling, 20 feet by 40 feet, topped by a steeply pitched gable roof covered with standing seam metal.

It rests on a low fieldstone foundation.

The family cemetery contains approximately a dozen stones marking the graves of the Sharpe and Barringer families.

[2] It was listed on the National Register of Historic Places in 2005.