It is located in the southwest of the krai and borders with Bogotolsky District in the north, Nazarovsky and Uzhursky Districts in the east, the Republic of Khakassia in the south and southwest, and with Kemerovo Oblast in the west and northwest.

The area of the district is 3,751 square kilometers (1,448 sq mi).

[2] Within the framework of administrative divisions, Sharypovsky District is one of the forty-three in the krai.

[11] A species Sineleutherus issedonicus was described by A. O. Averianov, A. V. Lopatin and S. A. Krasnolutskii in 2011.

It lived in what is now Sharypovsky District (Krasnoyarsk Krai, Russia) during the middle Jurassic (Bathonian age); its fossils were collected from the upper part of the Itat Formation.