[3] While at Whistling Woods, Khaitan worked on his first attempted film, Sherwani Kahaan Hai, with some of his fellow students, but it was not successfully completed.
[5] In 2008, Khaitan starred as Manohar in Roorkee By-Pass, a 22-minute drama directed by Arundhati Sen Verma,[6] and assisted on the set of Ghai's films Black & White and Yuvvraaj.
[7] After finishing the first draft of his script, then with the title Humpty Sharma Di Love Story, Khaitan sent it to Dharma Productions which approved producing it with a first time writer-director at the helm.
[13] in 2017, Khaitan co-wrote the screenplay and dialogue for the Hindi adaptation of John Green's 2012 novel The Fault in Our Stars with the intent to direct it for Dharma Productions with Janhvi Kapoor and Ishaan Khatter as leads.
[15] While Dhadak received negative reviews from film critics for glossing over the subject of caste-based discrimination and for being a poor remake of the original,[16] it emerged as a commercial success with worldwide earnings of over ₹1.1 billion (US$13 million).
[17][18] Khaitan turned producer for Dharma Productions with the comedy Good Newwz (2019), which emerged as one of highest-grossing Bollywood film of 2019 and the horror thriller Bhoot – Part One: The Haunted Ship (2020).
[20] Khaitan has completed working on the Vicky Kaushal, Kiara Advani and Bhumi Pednekar starter, a comedy thriller titled Govinda Naam Mera which is set to release on 10 June 2022.