He then hosted the satirical news comedy series Newstopia on SBS, the game show Talkin' 'Bout Your Generation on Network Ten, and Shaun Micallef's Mad as Hell on ABC TV.

He is also the author of several books: Smithereens (2004), Preincarnate (2010), The President's Desk (2014), Tales from a Tall Forest (2017), The Uncollected Plays of Shaun Micallef (2018), Mad as Hell and Back (2019), Happily Ever Afterwards (2021) and Tripping Over Myself, a memoir (2022).

[4] Micallef was influenced by the Goons,[1] Peter Sellers, Marx Brothers,[5] S. J. Perelman,[6] James Thurber, Spike Milligan,[7] Barry Humphries, Frank Muir,[8] Monty Python[9] and Woody Allen.

In 1972, having three younger sisters taking ballet classes, ten-year-old Micallef was often asked to help out when a dance routine required a boy.

[10] Micallef was a practising solicitor for ten years in the field of insurance law before making the decision to move to Melbourne and pursue a full-time career in comedy in 1993.

In 1994, Micallef became a full-time cast member of Full Frontal, where he became well known for characters such as Milo Kerrigan, Nobby Doldrums and a send-up of Italian male model Fabio.

Micallef recalls that the show was a good introduction to television comedy because, with an ensemble cast, its success did not hinge on his performance and he had more freedom to make and learn from mistakes.

He co-created Mr & Mrs Murder, a crime comedy television series for Channel Ten which aired in 2013, and starred in the lead role of Charlie Buchanan alongside Kat Stewart.

Also that year, Micallef signed on to voice the artificially intelligent robot RE3F in the Australian feature length science fiction film Arrowhead (2014).