It is the seventh track on their fifth studio album Americana (1998) and was released as the fourth and final single on October 19, 1999.

[3][4] As singer Dexter Holland described, "Today everyone has issues and no one takes responsibility because their mother or their father drank too much or whatever".

[6] The video, directed by Jonathan Dayton and Valerie Faris and animated by Wayne White,[7] shows a usual workday of a young adult woman (played by a pre-fame Zooey Deschanel), and the things in her everyday life that she finds disturbing or annoying, are enhanced by grotesque cartoons, which represent her imagination.

[8] On the Making the Video episode for "She's Got Issues", Dexter Holland described it as an "anti-video" for its highly conceptual nature.

Dexter Holland states on the DVD commentary for The Complete Music Video Collection that while he enjoyed working with the directors, he ultimately didn't feel that the video turned out how he thought it would.