Elliott performed the song live on a number of occasions, including the 2017 VH1 Hip Hop Honors: The '90s Game Changers.

"—then they jump right on it.Keith Farley of AllMusic wrote that Missy Elliott "reappropriates the insult to refer to strong females", considering it "the best example" of her "satirical nods to other clichéd notions of hip-hop" present throughout Da Real World.

[3] Writing for Rolling Stone, music journalist Touré praised "She's a Bitch" as "a furiously celebratory, slyly feminist anthem that reclaims an oppressive word, shattering its power to offend while burning down the clubs with a blazing beat and her roaring flow".

[4] By contrast, in an otherwise positive review of Da Real World, David Browne of Entertainment Weekly dismissed "She's a Bitch" as "one of the album’s most unremarkable and most cluttered tracks", criticising its selection as the lead single.

Highlights of the video include Elliott and her dancers being raised from underwater on a giant hydraulic "M", and also a complete set made from electroluminescent lighting.