Mary Ann is happily reunited with Michael Tolliver and Anna, but things are more complicated with her ex-husband, Brian Hawkins, and Shawna, the daughter she left behind to pursue a broadcasting career.

[4] A subsequent April 23, 2018, announcement included a production order for ten episodes, with the series to be written by Lauren Morelli, who would serve as showrunner and executive producer, alongside an all-LGBTQ writer's room.

Other executive producers would include Maupin, Alan Poul, Laura Linney, Andrew Stearn, Liza Chasin, Tim Bevan, and Eric Fellner.

[9] Alongside the initial series development announcement, it was reported that Laura Linney and Olympia Dukakis would reprise their roles as Mary Ann Singleton and Anna Madrigal, respectively.

[5] In October 2018, it was announced that Paul Gross would reprise his role of Brian Hawkins and that Murray Bartlett, Charlie Barnett, Josiah Victoria Garcia, and May Hong had also joined the main cast.

The critics' consensus states, "Like a pleasant visit to a place you used to live, Tales of the City provides ample nostalgic comforts and continues the series' mission of celebrating the diversity of San Francisco on its own terms.