[20] However, she was active on the youth athletics scene, competing in the famous Inter-Secondary Schools Boys and Girls Championships (known locally as "Champs"), and winning 100 m bronze at age 16.

[27] At the time, Francis was the head coach at the MVP (Maximising Velocity and Power) Track Club, and had guided the career of former 100 m world record holder Asafa Powell.

[22][29] In August, she again won the 100 m at the Stockholm DN-Galan, posting 11.57 s.[30] At the World Championships in September, Fraser-Pryce ran only in the relay heats, helping her team place second.

[31] Despite her initial anxiety towards competing at the World Championships, Fraser-Pryce credited her experience in Osaka for raising her confidence, changing her attitude towards athletics, and for making her much more focused.

[24] She won her heat in 11.35 s, her quarterfinal in 11.06 s, and her semifinal in 11.00 s.[36][37] In the 100 m final, she led a Jamaican sweep of the medals, trailed by Sherone Simpson and Kerron Stewart who both posted 10.98 s for silver (no bronze was awarded).

"[48] Stewart equalled her own personal best of 10.75 s for silver, while Carmelita Jeter of the United States (10.90 s) prevented another Jamaican podium sweep by beating Campbell-Brown (10.95 s) to the bronze.

"[48] Days later, she added a second gold medal at the championships as part of Jamaica's 4 × 100 m relay team, running alongside Stewart, Simone Facey and Aleen Bailey.

[63] Her first international race of the season was at the Prefontaine Classic on June 4, where she finished fourth in 10.95 s behind Carmelita Jeter (who ran a world leading 10.70 s), Marshevet Myers of the U.S. (10.86 s) and Kerron Stewart (10.87 s).

[66][67] At the championships, she placed second in her 100 m heat in 11.13 s, then first in her semifinal in 11.03 s.[68] In the world 100 m final, she started quickly but could not maintain the lead, finishing fourth in 10.99 s, and missing the podium by 0.01 s.[69][70] Gold went to Carmelita Jeter in 10.90 s, while compatriot Veronica Campbell-Brown (10.97 s) and Kelly-Ann Baptiste of Trinidad and Tobago (10.98 s) collected silver and bronze respectively.

[74][75] At the Beijing Olympics, Jamaica captured five of a possible six gold medals in the sprints, with Fraser-Pryce and Campbell-Brown winning the women's 100 m and 200 m respectively, and Usain Bolt dominating the men's 100 m, 200 m, and 4 × 100 m relay.

[81][82] By June, she was in winning form, cruising to victory at the Adidas Grand Prix in 10.92 s.[83] Weeks later, she won the sprint double at the Jamaican Olympic Trials in Kingston.

[61][90] Jeter claimed silver in a season's best 10.78 s,[91] and Campbell-Brown earned bronze in 10.81 s.[90][92] With her win, Fraser-Pryce joined Americans Wyomia Tyus (1964, 1968) and Gail Devers (1992, 1996) as the third woman to defend an Olympic 100 m title.

[102] Fraser-Pryce attributed her successful year to an increase in focus on her track career (after finishing school in November 2012)[103] and a new training regimen that emphasised the 200 m.[104][105] She admitted to previously "hating" the longer sprint, and was hesitant to fully embrace the title of a "100 m/200 m sprinter.

In the Diamond League, she won the 100 m in Doha in early May, posting 11.13 s.[121] However, she struggled with shin splints for the rest of her season, resulting in poor showings on the international circuit.

[127][128] Speaking at the Meeting de Paris in July, she stated that although the longer sprint helped to improve her speed endurance for the 100 m, her coach believed she had lost some of her explosiveness from the blocks.

"[136] American Tori Bowie earned bronze in 10.86 s.[134] With the victory, Fraser-Pryce became the second woman in history after U.S. sprinter Marion Jones to defend a 100 m world title.

[32][137] She also became the first woman to win the biennial title three times, matching the career hauls of Usain Bolt, as well as Americans Carl Lewis and Maurice Greene.

"[135] Days after her historic win, Fraser-Pryce anchored the women's 4 × 100 m relay team, consisting of Veronica Campbell-Brown, Natasha Morrison and newcomer Elaine Thompson, to gold.

[67][144] In her season opener at the Prefontaine Classic in May, she finished last in 11.18 s.[148][149] In the weeks before the Olympics, Fraser-Pryce struggled to reach form, clocking 11.25 s in Italy and 11.06 s at the London Grand Prix.

[151][152] In a highly competitive year that saw many of her rivals post multiple sub-10.90 s times, Fraser-Pryce's lone sub-11 s clocking of 10.93 s ranked her the eighth fastest in the world heading to the Olympics.

[22][168] In the 100 m final at the Jamaican Championships, she had a quick start but finished second to double Olympic champion Elaine Thompson in a season's best 11.09 s.[169] In July she took to the international circuit for several Diamond League meets, all while breastfeeding for her first 15 months after giving birth.

[203] Days later, she placed first at the Doha Diamond League in 10.84 s.[204] On June 5, 2021, she ran a new personal best, a new world lead and new Jamaican record of 10.63 s at the JAAA Olympic Destiny Series meet in Kingston, becoming the fastest woman alive (at the time).

[205][206] The quickest 100 m in over 33 years, her 10.63 s improved on the previous national record of 10.70 s that she shared with Elaine Thompson-Herah, and placed her ahead of American sprinters Carmelita Jeter (10.64 s) and Marion Jones (10.65 s).

"[207][208] At the Jamaican Olympic Trials at the end of June, Fraser-Pryce won the 100 m title in 10.71 s, ahead of Shericka Jackson (10.82 s) and defending national champion Elaine Thompson-Herah (10.84 s).

I ran the worst race that I could have ran, and I felt like I never gave myself the chance to compete in the best way I could.” In a Jamaican sweep of the podium in the Olympic 100 m final, Fraser-Pryce finished second behind defending champion Thompson-Herah in 10.74 s.[212][213] Jackson secured the bronze in a personal best 10.76 s.[214] Thompson-Herah's winning time of 10.61 s was a new Olympic record, a new national record and moved her ahead of Fraser-Pryce as the fastest woman alive.

[224][225] Women's sprinting also began to take centre stage in athletics[226] due in large part to the fierce rivalry between Fraser-Pryce and Thompson-Herah, as well as the rise of flamboyant American sprinter Sha'Carri Richardson.

[251][252] Fraser-Pryce withdrew from the Lausanne Diamond League at the end of August due to hamstring discomfort, and returned for the Memorial Van Damme a week later, where she finished second to Jackson (10.73 s to 10.74 s) in her only 100 m loss of the year.

"[128] In 2019, sports writer Steve Keating declared Fraser-Pryce the new face of athletics, stating that the birth of her son and her determination to return to the top added to her legacy.

"[50] In a biomechanical analysis of her performance in the 2009 world 100 m final (when she ran 10.73 s), sports scientists Rolf Graubner and Eberhard Nixdorf calculated her 30 m split at 4.02 s, a level of acceleration consistent with a male 10.40 s runner.

[319] On her Facebook page she wrote, "All my focus heading into training for my 2017 season was on getting healthy and putting myself in the best possible fitness to successfully defend my title in London 2017, but ... here I am thinking about being the greatest mother I can be.