He appeared as Yugoslav guerrilla leader Lt. Aleksa Petrovic, an aide to General Draza Mihailovich, in the 20th Century Fox war film Chetniks!

[5] He played Edgar Allan Poe in The Loves of Edgar Allan Poe (1942) and also appeared in Strange Triangle (1946), Fighter Squadron (1948), The Reckless Moment (1949), The Red Pony (1949), Under the Gun (1951), and A Place in the Sun (1951), starring Elizabeth Taylor and Montgomery Clift, as the Taylor character's father.

He portrayed Adam Stanton, the idealistic doctor who finally kills Willie Stark (played by Broderick Crawford) in the classic film All the King's Men (1949).

Strudwick made many appearances on television, including the role of Dr. Charles Morris in the 1958 Perry Mason episode, "The Case of the Fugitive Nurse."

[citation needed] Strudwick acted in at least 30 Broadway plays, beginning with The Yellow Jacket (1929), and ending with To Grandmother's House We Go (1981).