The Université de Sherbrooke has five campuses: The Université de Sherbrooke was established in 1954 as a French-speaking Catholic university in a region that had historically been English speaking, the Estrie, or Eastern Townships in English.

Initially there was a religious component to the pedagogical activities, but by the end of the 1960s the number of priests working for the university had greatly diminished during the Quiet Revolution.

In 1975, the appointment of a layman as Rector marked the end of religious activity in the institution.

[3] Université de Sherbrooke's arms, supporters, flag, and badge were registered with the Canadian Heraldic Authority on January 15, 2004.

[4] Université de Sherbrooke's crest and Supporters were registered with the Canadian Heraldic Authority on April 20, 2007.

Today it offers more than 90 educational programs, primarily at the master's level, in eight of the nine faculties of the university (Administration; Education; Engineering; Law; Letters and Humanities; Medicine and Health Sciences; Science; Theology, Ethics and Philosophy).

Whether at the undergraduate or graduate level, most programs are offered on a part-time basis on evenings and weekends, or in various intensive formats to allow professionals to remain in the work force.

Also opening in 1996, the Joint Campus in Moncton, New Brunswick, offers medical training to French-speaking students.

The University of Sherbrooke offers a variety of bachelors, masters, doctoral and post-doctoral programs as well as various certificates and microprograms.

Published three times a year by the Communications Service, this magazine is distributed free to everyone in the central graduate database and to staff as well as friends of the institution.

It is a member of several external organizations, having formerly been affiliated with the Fédération étudiante universitaire du Québec (FEUQ), the Quebec Federation of University Students.

Since 2005, when it was accredited as sole representative of all students in the faculty, the association has fought against the monopoly held by a food-distribution company on the Sherbrooke Main Campus.

Founded in 1969, the Association générale des étudiants en médecine de l’Université de Sherbrooke represents medical students attending the university's various satellite campuses (Longueuil, Chicoutimi, Moncton).

On March 17, 2010, the AGES won the Continuity Prize awarded by the FEUS at the Défi Étudiant for their 51 years of service.

The Association des étudiants en éducation physique of the Université de Sherbrooke represents students in the Faculty of Sports and Physical Education.

The Regroupement des étudiants de cycles supérieurs en études politiques represents political science students.