[15] Sherelle's breakthrough was with her 2019 Boiler Room DJ set, which went viral and allowed her to take up music full-time.
[3][6][16] In September 2019, she participated in the BBC Radio 1 residency series, featuring guestmixes and interviews from 4hero, Goldie, and Virgil Abloh.
[25] Pitchfork described the mix as "compressing decades of dancing to tightly woven two- and three-minute segments" which "catalogs a moment in which a new generation is grasping and reshaping a raving past that's too distant for them to remember.
"[24] Until its disbandment in January 2022, Sherelle was a member of the all-female and non-binary DJ group 6 Figure Gang.
[26] From 16 September 2023, SHERELLE started hosting a new weekly show on BBC Radio 6 Music airing on Saturday nights, following the departure of fellow DJ The Blessed Madonna.