In 1999, at the age of nine, Sherina made her debut album Andai Aku Besar Nanti (When I Grow Up) under Tantowi Yahya's label Ceepee Productions.

Gumilang Ramadhan (general manager of Sony BMG Indonesia) said, "part of the profit from the sales will be given to Indonesian children through an international charity foundation".

Also on the same year, she recorded a cover of "I Have A Dream" with Irish boyband Westlife to raise funds for UNICEF[13] and received a special award in the "Most Talented Child Artist" category in the 2001 Asia Pacific Film Festival in Hanoi for her performance.

[4] In June 2001, Sherina sang "Simfoni Raya", written by Guruh Sukarnoputra for his album Bakti dan Persembahanku, released to celebrate the centenary anniversary of the birth of Indonesia's founding president Sukarno.

[15] To shed her child star image, Sherina signed to Trinity Optima Productions and released her fourth album, Primadona, on 14 March 2007, spewing out two singles: Sendiri and Ku Disini.

Both soundtracks appeared on Gemini, which spewed three singles: Cinta Pertama dan Terakhir, Geregetan (technically a cover of her father's song from his band days) and Pergilah Kau.

[17] It spawned three singles: Sebelum Selamanya, Akan KuTunggu, and Apakah Ku Jatuh Cinta (a collaboration with labelmate Vidi Aldiano).

[30] Before achieving success as a child singer, Sherina's nascent acting skills had attracted the attention of the Miles Production film company, which thought she would fit nicely into a musical they were planning, called Vera and Elmo's Adventure, to be directed by Riri Riza.

The simplicity of the story and its old-fashioned family entertainment made it a popular film during the period of Indonesia's transition from an authoritarian regime to democracy.

[33] Released in June 2000, Sherina's Adventure sold 1.4 million tickets in six months and earned an estimated $723,000 from a budget of $241,000.

Vidi Aldiano With Derby Romero Sherina signed to be a judge on The Voice, which debuted on Indosiar in February 2013.

Sherina serves as a coach, alongside fellow musicians Armand Maulana, Giring Ganesha and Glenn Fredly, with Darius Sinathriya and Fenita Arie as the show's host.