She appeared in a lot of hit TV shows from GMA Network such as Best Friends, Beh Bote Nga, Te Amo, Maging Sino Ka Man, Mulawin, Impostora, MariMar, Paroa: Ang Kuwento ni Mariposa, Anna KareNina and Carmela.

She was also a co-host in the longest-running late-night variety TV show in the Philippines, Walang Tulugan with the Master Showman in which she showcase her talent in singing and hosting.

A graduating Broadcasting major in Centro Escolar University, Santiago started singing in hotels and doing lounge performances at the age 16.

[2] In 2012, Santiago got her breakthrough role in the drama-fantasy TV show, Paroa: Ang Kuwento ni Mariposa, where she portrayed the villainous femme fatale butterfly Talisay.

In 2013, for her 32nd birthday, she performed Adele's song "Someone Like You" on Walang Tulugan with the Master Showman and received a standing ovation from the audience.