[5] He made his Twenty20 (T20) debut in the 2016 Caribbean Premier League (CPL) for the Guyana Amazon Warriors, and was retained for the 2017 edition.

[6] In August 2018, he became the youngest batsman to score a century in the CPL, when he made 100 runs for Guyana Amazon Warriors against the Jamaica Tallawahs.

[10][11] In March 2019, he was named as one of eight players to watch by the International Cricket Council (ICC) ahead of the 2019 Indian Premier League tournament.

[21] In December 2017, he was added to the West Indies' One Day International (ODI) squad ahead of their series against New Zealand.

[25] On 6 March 2018, in the 2018 Cricket World Cup Qualifier, he scored his first ODI century,[26] batting against the United Arab Emirates at the Old Hararians ground in Harare.

[29] In February 2019, Hetmyer scored the fastest century by a West Indies batsman against England in an ODI match, doing so from 82 balls.