Mikimoto made his debut in 1953 as a small role of "Battleship Yamato" directed by Yutaka Abe.

[4] Primarily a supporting actor, Mikimoto frequently appeared as a bad guy in jidaigeki on television and in film.

Many other long-running jidaigeki cast Mikimoto in guest-star roles, among them Abarenbō Shōgun, Zenigata Heiji, Onihei Hankachō (on which he was also a regular character), Ōoka Echizen, and Chōshichirō Edo Nikki.

In film, Mikimoto appeared in Gion Matsuri (1968) with Kinnosuke Nakamura and Toshiro Mifune; The Fall of Ako Castle (1978), directed by Kinji Fukasaku and starring Nakamura, Mifune, and Sonny Chiba; and films set in modern times such as Zero Fighter Burns and the 1986 The Return of Godzilla with Raymond Burr and Japan Academy Prize-winning actress Yasuko Sawaguchi.

This article incorporates material from 御木本伸介 (Mikimoto Shinsuke) in the Japanese Wikipedia, retrieved on March 15, 2008.