He has been cited as an influence on popular western filmmakers such as Quentin Tarantino, David Fincher, Darren Aronofsky and The Wachowskis.

[7] He made a number of films, ranging from 10-minute shorts to 2-hour features, until his first year at college when he temporarily lost interest in filmmaking.

At the end of production, Tsukamoto did not want to waste all the effort they had put into building the set, so he decided to shoot a film version.

[11] In Body Hammer, the son of a salaryman (Taguchi) is kidnapped by a group of thugs, who then force the man's nascent rage to make him mutate into a gigantic human weapon.

His single minded behaviour causes him to run afoul of a gang of thugs, especially when he shows interest in the young girl who is one of their compatriots.

Tsukamoto has appeared in many other directors' films as well, such as Takashi Miike's Dead or Alive 2: Birds (2000) and Ichi the Killer (2001), as well as Teruo Ishii's Blind Beast vs.

He also provided the Japanese voice of Vamp in the 2008 PlayStation 3 game Metal Gear Solid 4: Guns of the Patriots.

Tsukamoto was originally set to play the character in Metal Gear Solid 2: Sons of Liberty (after Hideo Kojima's first choice, Kaneto Shiozawa, died before casting began) but was unavailable due to scheduling conflicts, so Ryōtarō Okiayu was assigned the role instead.