Born in Accra, Botchwey had her secondary education at St. Mary's Girls' Senior High School at Korle-Gonno.

A member of the ECOWAS Parliament from 2013 – 2017, she worked with her colleagues to assist the Community Parliament in its advisory role in considering matters concerning the region particularly on issues relating to fundamental human rights and freedom, while making recommendations to institutions and organs of ECOWAS.

On 21 January 2021, she was nominated as the minister for Foreign Affairs and Regional Integration by the president of Ghana, Nana Akuffo-Addo.

[16] Before entering into frontline politics, Botchwey ran a marketing and communications Company where she was a consultant for the Ministry of Tourism.

[17] As a practitioner of public administration, she worked with various organizations such as Worldspace Ghana, the Divestiture Implementation Committee, Glaxo Group Research and Hodge Recruitment.