Shirley Reilly (born May 29, 1985) is an American wheelchair racer who competes in track races and the marathon distance in the T53/T54 categories.

Her early life was marked by frequent operations, including surgery around 1997 when she had eight spinal discs and two ribs removed.

Reilly took part in competitive sports at high school and focused on track athletics.

She was runner-up in the wheelchair section of the Los Angeles Marathon in 2005 and returned to following year to win the race.

[7] Later that month she took part in the London Marathon for the first time and came in fourth after Canada's Diane Roy.