Shirley A. Smith (born November 29, 1950) is an American politician who served as a member of the Ohio Senate from 2007 to 2014.

When incumbent C. J. Prentiss decided to run for the Ohio Senate, Smith and four other Democrats sought to replace her in the 1998 primary election.

In late 2005, Smith announced that she would run to succeed term-limited Prentiss in the Senate, along with Representatives Annie L. Key, Claudette Woodard and two other Democrats.

With the beginning of the 128th General Assembly, the caucus retained Smith in her role as assistant minority leader under Capri Cafaro.

On January 19, 2021, Smith declared her candidacy in the Democratic primary for the 2021 special election in Ohio's 11th congressional district.