Wosner was born in Vienna, Austria-Hungary and studied in the Yeshivas Chachmei Lublin of Poland led by Rabbi Meir Shapiro.

Wosner is the author of several works of Jewish law, including Shevet HaLevi ("The Tribe of Levi"), a comprehensive series of halakhic rulings and responsa on Jewish laws comprising ten volumes, and several other Torah books all bearing the same name.

On May 20, 2012 Ichud HaKehillos LeTohar HaMachane held an asifa (gathering) at Citi Field in Queens to address the dangers of the internet.

Wosner was buried late Saturday night, April 4, 2015, in a funeral attended by an estimated 100,000 people.

[3] Severe overcrowding in front of Rabbi Wosner's yeshiva, where his body lay in repose, led to the trampling of three men and a 14-year-old boy.