The company has locations in Sevenum, Cologne, Berlin, Munich, Warsaw, Milan, Lille, Eindhoven and Tongeren.

Shop Apotheke began its international expansion in 2012 with the launch of the Austrian webshop shop-apotheke.at, followed three years later by Belgium and France.

[3] International expansion continued with the acquisition of the Belgian online pharmacy group Farmaline in 2016 and the associated market entry in Italy and the Netherlands.

The following year, Shop Apotheke Europe acquired Europa Apotheek, which specialized in the sale of prescription medicines to customers in Germany.

In 2018, Shop Apotheke Europe expanded with the acquisition of the Berlin-based company nu3, which sells functional nutrition products.