Short-chain acyl-coenzyme A dehydrogenase deficiency (SCADD) is an autosomal recessive[6] fatty acid oxidation disorder which affects enzymes required to break down a certain group of fats called short chain fatty acids.

[medical citation needed] Short-chain acyl-coenzyme A dehydrogenase deficiency affected infants will have vomiting, low blood sugar, a lack of energy (lethargy), poor feeding, and failure to gain weight and grow.

Additional features of this disorder may include poor muscle tone (hypotonia), seizures, developmental delays, and microcephaly.

The parents of an individual with an autosomal recessive disorder both carry one copy of the defective gene.

[5] In terms of treatment for this condition, short-chain acyl-CoA dehydrogenase deficiency, some individuals may not need treatment, while others might follow administration of:[7] This disorder, epidemiologically speaking, is thought to affect approximately 1 in 50,000 newborns according to Jethva, et al.[6] While in the U.S. state of California there seems to be a ratio of 1 in 35,000.