Ishinomori then created many similar superhero dramas, which were once again all produced by Toei or in Sarutobi Ecchan's case Toei Animation, including Android Kikaider, Kikaider 01, Henshin Ninja Arashi [ja], Inazuman, Robotto Keiji, Himitsu Sentai Gorenger (the first Super Sentai series), Kaiketsu Zubat, Akumaizer 3, Sarutobi Ecchan, the Toei Fushigi Comedy Series, and countless others.

[citation needed] The true story of his first meeting with Tezuka was illustrated in a short four-page tale drawn up as supplementary material for the 1970s Astro Boy manga reprints.

In 1954, Ishinomori submitted his first official work, Nikyu Tenshi, to a contest seeking new talent in the magazine, Manga Shōnen.

Tezuka was impressed by his drawings and sent a telegraph to Ishinomori, asking him to work as his assistant with Astro Boy.

[citation needed] Ishinomori illustrated a comic adaptation of the Super NES video game The Legend of Zelda: A Link to the Past, which was produced for the American publication Nintendo Power.

Ishinomori, who had been one of Shimamoto's boyhood heroes, faxed him copies of the proposed story and plot notes.

His work posthumously awarded him the Guinness World Record for most comics published by one author, totaling over 128,000 pages across 770 titles across 500 volumes.

[12] His influence, particularly on superhero media, is such that he has often drawn comparisons as being the manga counterpart to both Stan Lee[13] and Jack Kirby.

[14] Many manga artists have cited Ishinomori as an influence, including Katsuhiro Otomo, Naoki Urasawa, Go Nagai, Kazuhiko Shimamoto, Keiko Takemiya, Moto Hagio, Taiyo Matsumoto, Tetsuya Chiba and Tetsuo Hara.