The 100-acre (0.40 km2) grounds include a visitors' center and outdoor devotional areas such as a rosary walk, Stations of the Cross, and a votive candle chapel.

The first phase of construction included a Pilgrim Center, which features an orientation room, information desk, the Flores Mariae gift shop, and the Culina Mariana restaurant, and the Mother of Good Counsel Votive Candle Chapel.

The second phase included an outdoor Stations of the Cross, a devotional area to Saint Joseph the Workman and a rosary walk, in addition to construction on the shrine church.

In August 2021, the Norbertine canons of St. Michael's Abbey took over pastoral care of the shrine from the Franciscan Friars of the Immaculate.

In July 2011 Pope Benedict XVI affiliated the shrine church to the papal basilica of St. Mary Major in Rome,[10] which inspired much of the interior design.

[9] The dome ceiling features a turquoise sky with gold-leaf constellations composed with assistance from astronomers at the Talcott Mountain Science Center in Avon, Connecticut.

There are also three paintings by Brett Edenton in the lower narthex of the church that depict Samuel Mazzuchelli, Frederic Baraga, and Solanus Casey.

This area includes a fountain and a bronze relief designed by Anthony Brankin showing Saint Joseph the Workman instructing Jesus.

Background images depict Archbishop Burke, founder of the shrine, and Mr. and Mrs. Robert Swing, donors of the land.

This secluded devotional area features a larger-than-life-sized bronze statue of Kateri Tekakwitha, Lily of the Mohawks, by artist Cynthia Hitschler.

The work depicts Kateri in native buckskin in a natural setting, kneeling in reverence to a rough, hand-made cross, with a basket at her side filled with strawberries, a calla lily and the three "sister" plants; corn, squash and beans.

Also, there is a series of plaques that present teachings of the Catholic Church on abortion, contraception, embryonic stem cell research, and the dignity of the human person.

The Flores Mariae is a gift shop in the Pilgrim Center that provides literature about the Catholic faith and other religious items.