Adjacent is the cloistered Monastery of the Poor Clare Nuns of Perpetual Adoration, situated on a 400-acre (160 ha) site and a religious center affiliated with the Eternal Word Television Network.

The shrine is named in honor of the Blessed Sacrament, while the building surroundings are dedicated to the Divino Niño, a title of the Child Jesus found prominently displayed all over the area.

In 1995, while travelling to Colombia to seek assistance for EWTN's Spanish-language programs, Mother Angelica attended Mass at the Sanctuary of the Divine Child Jesus in Bogotá and was inspired to build a shrine honoring the real presence of Christ in the Eucharist.

Mother Angelica sought to model the Shrine on 13th century Italian architecture, with its piazza or plaza square, colonnade, esplanade and various cosmatesque designs.

[4] The shrine consists of a cloistered monastery, upper and lower church, near life sized nativity scene, Lourdes grotto, castle which houses the gift shop and conference rooms, and John Paul II Eucharistic Center.