Her television work includes Cape Wrath (2007), Sherlock (2017), Doctor Foster (2017), Good Omens (2019), Guilt (2019), Trying (2020–), House of the Dragon (2022), and Blue Lights (2023-).
[7] Brooke's theatre work includes Harvest, Dying City, Dido Queen of Carthage, In The Club, The Birthday Party, “I’m Not Running” and Absolutely Perhaps.
She has also appeared in productions of Poor Beck, A Midsummer Night's Dream, King Lear and Romeo and Juliet, with the Royal Shakespeare Company.
[11] Michael Hogan writing for The Daily Telegraph in his review of the third episode of the series commented that the role was "a star-making turn from Siân Brooke".
[12] Later in the year, she appeared with Sheridan Smith and Gemma Whelan in the BBC miniseries The Moorside, based on the kidnapping of Shannon Matthews.