The park, centred on the Srinagarind Reservoir, is part of the Western Forest Complex protected area.

Khuean Srinagarindra National Park is 105 kilometres (65 mi) northwest of Kanchanaburi town in Sai Yok, Si Sawat and Thong Pha Phum districts.

[4] Park animals include Asian elephant, tiger, gaur, lar gibbon, Phayre's leaf monkey and sambar.

[4] Bird life features species such as olive-backed sunbird, Oriental pied hornbill, red junglefowl, scaly-breasted munia, scarlet-backed flowerpecker and thick-billed green pigeon.

[4] Freshwater fish species in the park include giant snakehead, ocellated featherback (Chitala ornata), greater brook carp (Tor tambroides), yellow mystus and transverse-bar barb.