[3] Very little is known about the natural history of this species in the wild, but females build mound-nests constructed from scraped-up plant debris mixed with mud.

[19] Siamese crocodiles are under threat from human disturbance and habitat occupation, which is forcing remaining populations to the edges of their former range.

[24][25] Factors causing loss of habitat include: conversion of wetlands for agriculture, chemical fertilisers use, use of pesticides in rice production, and an increase in the population of cattle.

[27] Many river systems, including those in protected areas, have hydroelectric power dams approved or proposed, which are likely to cause the loss of about half of the remaining breeding colonies within the next ten years.

[11] One cause for habitat degradation via hydrological changes, for the Siamese crocodile, is the implementation of dams on the upper Mekong River and its major tributaries.

[28] Potential impacts of dam construction include wetland loss and altered flooding cycle with a dry season flow 50% greater than under natural conditions.

[12] Yayasan Ulin (The Ironwood Foundation) ran a small project to conserve an important wetland habitat in the area of East Kalimantan which is known to contain the crocodiles.

Since 2012, approximately 50 purebred Cambodian Siamese crocodiles have been released into community-protected areas to reinforce the depleted wild populations.

[22] The Wildlife Conservation Society (WCS) is working with the government of Laos on a new programme to save this critically endangered crocodile and its wetland habitat.

[39] In Cambodia's Southern Cardamom National Park, sixty Siamese crocodiles from five distinct nests successfully hatched in July 2024.

This marks the largest wild breeding record of the species this century and significantly enhances the survival prospects of this critically endangered reptile.

[43] A Siamese crocodile has been cited in the Thai folklore of Central Thailand's Krai Thong ("ไกรทอง") tales have known as well,[44] and was taken to create a television series and movies several times.

It was remarkable as historians recorded it as one of the first pieces ever written in the demotic script Chữ Nôm instead of classical Chinese; the emperor amply rewarded the scholar for his literary deed.

It marked a shift in Vietnamese literature as the Nôm script gained significant traction as a worthy vehicle for literary works.