China National Highway 318 (G318) runs from Shanghai to Zhangmu on the China-Nepal border.

It is the longest China National Highway at 5,476 kilometres (3,403 mi) in length and runs west from Shanghai towards Zhejiang, Anhui, Hubei, Chongqing, Sichuan, and ends in Tibet Autonomous Region.

At the Sino-Nepal Friendship Bridge, it connects with the 115 km long Araniko Highway to Kathmandu.

The route is popular with tourists due to the wide variety of biomes, cultural areas, and natural scenery.

Another extension plan was announced in 2022, including new small purpose connection highways (601-701).