[3] Pilkington stars as both lead characters, playing his namesake Karl, and the voice inside his head that takes the form of his Doppelgänger.
The series is set around Ladbroke Grove in London and follows Karl, a bored taxi driver who has been dumped by his girlfriend Zoe and moves in with his elderly American aunt Norma, and is struggling to get his life back on track.
In Series 2 Norma's carer Ruby is played by Marama Corlett who also becomes a love interest for Karl.
Sick of It doesn’t have a regular fixed cast and instead features guest appearances each week from actors including Craig Parkinson, Kate Ashfield, Perry Benson, Finn Bennett, Remy Beasley, Mark Silcox, Raad Rawi, David Vujanic, Cokey Falcow, Lou Sanders, Shola Adewusi, Cavan Clerkin, Julia Krynke, and Doug Stanhope.
Lucy Mangan from The Guardian gave the first two episodes 3 out of 5, observing, "It may not have been pure Pilkington, but perhaps in these melancholy times we couldn’t cope with that simple, shining joy anyway.