In contrast, beta-thalassemia alleles can be created by many different mutations including both deletion and non-deletion forms.
[citation needed] Patient may present with symptomatic anemia or with sickle crises.
In the United States and other countries with new-born screening programs, the disease may be identified in neonates.
[4] Diagnostic tests include DNA sequencing, hemoglobin electrophoresis, and high-performance liquid chromatography.
Patients may receive hydroxyurea to induce the protective effects of increased fetal hemoglobin production.