As an inker on DC Comics series including Batman, Green Lantern, Justice League of America and The Atom, he helped to define the company's house style for its 1960s Silver Age superheroes.

[3][4] His first science fiction for DC was the eight-page "Earth Is the Target" in Mystery in Space #26 (July 1955), an anthology series in which Greene and writer Gardner Fox would co-create the team Star Rovers in issue #66 (March 1961).

He also drew all six issues of DC's The New Adventures of Charlie Chan (June 1958 - April 1959),[4] starring the long-running fictional Chinese-American detective of novels and films.

Greene soon became, as well, one of the regular Batman inkers in Detective Comics, including on issue #359 (Jan. 1967), the debut of Batgirl,[7] with penciler Infantino — all while continuing to ink the adventures of the previous three characters mentioned.

In addition to all this, Schwartz assigned Greene to succeed the retired Bernard Sachs as regular inker on the publisher's primary superhero-team series, Justice League of America, beginning with issue #46 (Aug. 1966).

His stories in The Unexpected #117 and House of Secrets #84 (both cover-dated March 1970, and drawn at least three months earlier) mark his final published works.