In 1992 he founded and joined the board of the Inter-African Union of Human Rights (l'Union interafricaine des droits de l'Homme) (UIDH), regional organization based in Ouagadougou (Burkina-Faso).

In 1995 he founded and presided the African Center for the Prevention of Conflicts − (Centre africain pour la prévention des conflits) (CAPREC), and the African Center for the study of human rights and democracy in Banjul (Centre africain pour les études des droits de l'Homme et de la démocratie) (ACDHRS).

As President of the FIDH he led inquiry and high-level missions to Colombia, the Russian Federation, the United States, Guatemala, Egypt, Israel, Chad, Democratic Republic of the Congo, Tunisia, Algeria, Ecuador, and Libya.

He has contributed to the training of human rights activists from Colombia, Nicaragua, United States, the Russian Federation, Turkey, Israel, Morocco, Zimbabwe and Chad.

As a lawyer in Dakar he has worked to bring numerous cases to Senegal and African tribunals to defend political activists and opposition leaders such as: He has also defended human rights activities: He has also served as defense lawyer of victims: Sidiki Kaba was appointed Minister of Justice of Senegal in 2013 by then Prime Minister Aminata Toure.

Along with the Ministers of Economy, Finance and Planning he represents Senegal at the Organizations for the Harmonization of Business Law in Africa (OHADA) He is also in charge with the establishment of the specialized Chambers and of overseeing the trial against Hissène Habré, the former dictator from Chad, and of the trial of the son of former president Abdoulaye Wade, Karim Wade on embezzlement charges.

Sidiki Kaba was elected President of the Assembly of States Parties to the Rome Statute of the International Criminal Court on 8 December 2014.

He is Laureate of the Prize for the Promotion of the Culture of Democracy in Africa (awarded by the Pan African Observatory of Democracy in Togo, in 2003), and is an Honorary Citizen of Quito, Ecuador (2004), Sidiki Kaba has lectured at the Ake Loba College of Abidjan, Côte d'Ivoire, the Human Rights and Peace Institute of the University of Dakar, Senegal and at Evry Val d’Esson University, France.