The siege of Agadir in 1533 was a military confrontation started by the troops of Mohammed al-Shaykh against the Portuguese fortress of Santa Cruz do Cabo da Gué.

Mohammed al-Shaykh had begun to dominate the lords and tribes of southern Morocco, so the Portuguese in Agadir saw any supplies from the interior cut off and reduced to the fortress grounds.

The Muslim leader intended to conquer Agadir to obtain a port that would allow him to export the sugar produced in Suz and understood the prestige he had to gain from the expulsion of Christians from that place.

Mohammed al-Shaykh fortified himself in two villages near Santa Cruz, where a large number of warriors had gathered since the beginning of 1533.

[1] On a certain day at the end of April or beginning of May, the fortress walls were scaled by surprise, the captain was murdered in his quarters and the Keep was invaded.