The siege of Tottori Castle occurred in 1581 and was part of Oda Nobunaga's campaign to consolidate his power in western Honshu in an effort to unite Japan during the late 16th century.

In late 1580, as part of his campaign to extend Nobunaga's domain to the west, Hashiba Hideyoshi moved north from his new base in Harima and by 1581 entered Inaba province on the Sea of Japan wherein his forces encountered Tottori castle.

Hideyoshi made efforts to negotiate with Tsuneie, but the Mori retainer was resolved to hold onto the castle and keep it from falling into Oda hands.

To this end, Hideyoshi drove the local villagers within the walls of the castle and all the approaches to Tottori were covered by erecting towers every 500 meters around the perimeter.

Hashiba Hideyoshi would return to his base at Himeji in Harima and continue westward along the San'yōdō through Bizen and into Mori-controlled Bitchu province, where in 1582 he would besiege the castle of Takamatsu.