The Nizam resolved the internal conflicts among the regional hereditary nobles (Nawabs) for the seat of governor (Subedar) of Arcot State, and monitored the activities of the British East India company and French East India Company by limiting their access to ports and trading.

On 11 October 1724, the Nizam defeated and killed Mubariz Khan, establishing autonomous rule over the Deccan region.

[7]: 98 [8]: 298–310 In the 1720s, the Carnatic region of southern India was an autonomous dominion of the Mughal Empire under the suzerainty of the Nizam of Hyderabad.

Dost Ali sent Chanda Sahib, his son-in-law and diwan, to the province and to claim that it owed tribute payments (chauth).

Chanda Sahib inveigled into the court of Rani Minakshi, abused her trust to the fortress, and threw her into prison where she died of grief.

But Chanda Sahib, confident of his defense, refused to negotiate with Raghoji I Bhonsle, pay tribute, or surrender control of Trichinopoly.

The Nizam demanded that Safdar Ali, who was recognized as the Nawab of Carnatic, settle the debts of Subah Deccan.

However, in January 1743, Dalavayi Devarajaiya of Mysore, after establishing his hold on the Carnatic region, offered the Nizam 10,000,000 rupees in exchange for Trichinopoly.

Murari Rao dressed in gauntlet decided to defend the fort with 4000 sepoy, 2000 Sowar and a considerable number of artillery that consisted of canons, guns, mortar and grenades.

Khwaja Abdullah accompanied the Nizam to Golconda and left his son, Nimathullah Khan, as the deputy governor of Trichinopoly.

Babuji Naik of Baramati led the first expedition, which was defeated when he was confronted by Anwaruddin Khan of Arcot and Muzaffar Jung, who had been assigned by the Nizam.

The second expedition took place in 1746, led by Babuji Naik and Fateh Singh Bhonsle of Akkalkot; they were unsuccessful at taking back Trichinopoly and were defeated by the Nizam's army.

[1]: 143 [31]: 30–35 [9] In 1746, three years after the siege, the Marathas, under the rule of Peshwa Balaji Bajirao, sent a military expedition to Carnatic led by Sadashivrao Bhau.

Maratha influence in the Carnatic subsequently waned, opening the way for the French and British East India Companies to split the region between themselves.

During his reign, he proposed renaming the city Natharnagar after the Sufi saint Nathar Vali, who is thought to have lived there in the 12th century.