[4] The college seal uses the Dominican Shield of the International Order of Preachers, consisting of four white and four black gyrons or triangles.

The motto surrounding the shield, "Laudare, Benedicere, Praedicare," means "to praise God, to bless His people and to preach His gospel".

[5] Siena Heights remains affiliated with and sponsored by the Dominican Sisters of Adrian, Michigan.

There are satellite campuses in Dearborn, Benton Harbor, Monroe, Battle Creek, Kalamazoo, Lansing, Jackson, and online.

[8] Its most popular undergraduate majors, in terms of 2021 graduates, were:[9] Siena Heights also provides classes for high school students through dual enrollment.

[10] The university is a member of the National Association of Intercollegiate Athletics (NAIA), primarily competing in the Wolverine–Hoosier Athletic Conference (WHAC) for most of its sports since the 1992–93 academic year; while its football team competes in the Mideast League of the Mid-States Football Association (MSFA) since the 2012 fall season.