[10] Sierra Hull was born and raised in Byrdstown, Tennessee and attended Pickett County High School before accepting a Presidential Scholarship to study at the Berklee College of Music.

[15] Hull has won ten International Bluegrass Music Association awards between 2010 and 2023, including winning best mandolin player in 6 out of the past 8 years (2016-2023).

[19] Hull's vocal debut album on Rounder Records, released in May 2008, was co-produced by Alison Krauss and Ron Block which follows a self-released CD Angel Mountain, in 2002.

Hull was a guest vocalist with lead singer James Adkins on the male-female duet "Love Song",[20] featured on the 2015 self-titled album from Americana group Big Virginia Sky.

NPR reviewer Jewly Hight called Weighted Mind a "stunning coming-of-age album," adding that "Hull has joined the rarefied company of Nickel Creek expats Chris Thile, Sara Watkins and Sean Watkins, pedigreed virtuosos whose youthful, searching musical minds have taken them into postmodern singer-songwriter territory and beyond.

Released on February 28, 2020, co-produced by Hull and producer / engineer Shani Gandhi, features guitarist Mike Seal, bassist Ethan Jodziewicz, violinist Alex Hargreaves, and fiddler Christian Sedelmyer, together with bassist Viktor Krauss, guitarist Bryan Sutton, multi-instrumentalist Stuart Duncan, and steel guitarist Paul Franklin, and guest appearances by Molly Tuttle, Ron Block, Mindy Smith, Ronnie Bowman, Katie Pruitt, Angel Snow, and Hull's husband, multi-instrumentalist Justin Moses.

Liam Lewis opined, "25 Trips is an eclectic album, with a contemporary feel, showcasing Hull’s songwriting and exceptional vocals, crystal clear but with emotion and character, on 13 songs, self and co-written on the pleasures and travails of becoming the person and the musician she is today.