There is evidence that the Aztecs worshipped Tonantzin (Goddess of Sustenance) at Tepeyac hill.

[1] The sierra is named after Our Lady of Guadalupe,[2] a Marian apparition that, according to oral and written colonial sources such as the Huei tlamahuiçoltica, Juan Diego saw at the Tepeyac hill.

[2] The sierra is a dormant volcano that is part of the Trans-Mexican Volcanic Belt.

[6] Among the species found in the sierra, it is included the Mexican pine snake, the American kestrel, the roadrunner, the opossum, and the bobcat.

Introduced species include the white-tailed deer, tapirs and bisons.