Some of the more common plants restricted to the region are Bidens cabopulmensis, Diospyros intricata, Erythranthe lagunensis, Heimia salicifolia, Hibiscus ribifolius, Indigofera fruticosa, Physalis glabra, Quercus brandegeei, Sida xanti, Stenotis asperuloides, and Yucca capensis.

The dry San Lucan xeric scrub ecoregion extends from the sea level at the coast to 250 metres (820 ft) in elevation.

The Sierra de la Laguna dry forests ecoregion occupy lower portion of the range, from 250–800 metres (820–2,620 ft) in elevation.

[2] The upper reaches of the mountains include endemic species such as a rare succulent plant Dudleya rigida, and a beargrass known as Nolina beldingii.

[4] UNESCO has designated the Sierra de la Laguna a global biosphere reserve: "This semi arid to temperate subhumid climate area represents highly important and contrasted ecosystems, including arid zones, matorrales, low deciduous forest type, evergreen oak: Quercus devia (“encino”) woods, pine-evergreen oak mix woods and oases with palms and “guerivos” situated throughout the gallery forest following the long river basins."