In 1787 he moved to Berlin, where he conducted private lectures on chemistry, physics, technology and pharmacy.
In 1781 he was appointed professor of chemistry and pharmacy at the Collegium Medico-chirurgicum in Berlin.
[1] In 1808 he became a full member of the Prussian Academy of Sciences, and three years later was appointed professor of technological chemistry at the University of Berlin.
[2] In 1828 the botanical genus Hermbstaedtia (family Amaranthaceae) was named in his honor.
He was also the author of numerous treatises on various subjects associated with agriculture and industry, such as: producing sugar from beets; the manufacture of soft and hard soap; the chemical principles of beer brewing; the cultivation of tobacco and the preparation and processing of flax and hemp.