The Sigma Alpha Epsilon Building is a historic Sigma Alpha Epsilon fraternity house located near the University of Missouri at Columbia, Missouri.

The building took its present form in 1929 under the direction of architect Fred Wallace of Marchall and Brown.

Wallace attended the University of Missouri for two years and joined Sigma Alpha Epsilon fraternity.

Its front facade features a central pedimented portico with six two-story stone Ionic order columns.

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