Sigma Theta Epsilon (ΣΘΕ) was an American interdenominational national Christian fraternal organization that operated from 1925 to 2022.

A group of Methodist men in the Wesley Foundation at the University of South Dakota, Vermillion, South Dakota, had been carrying on a program as a religious fraternity, which they called Phi Lambda Phi, for some time when it occurred to them that perhaps the men in other Wesley Foundations had similar groups which could be mutually helpful if they should form a union.

They sent an invitation to all Wesley Foundation units asking those interested to send representatives to an organizational meeting.

After a period of expansion, the inactivity of the chapters (high in number – low in spirit) persuaded the national conclave of 1968 to appoint a committee to examine the philosophy of the fraternity.

The addition of a new Delta chapter, the second of that name, at Mount Union College in April 1980 stimulated new optimism and growth for the fraternity.

The fraternity didn't see National Growth again until 1998, when on January 31, the Beta Gamma chapter was initiated at the University of Cincinnati.

Spring Conclave 1999 saw the formal initiation of a group of men from Our Lady of the Lake University in San Antonio, Texas as Beta Delta chapter.

At the 2000 Spring Conclave, a group of men from Bradley University in Peoria, Illinois pledged as a temporary club.

These same men were formally initiated as the Beta Epsilon chapter at The English Chapel at Ohio Northern University during the East Regional Fall Gathering on October 21, 2000.

On April 5, 2003, the Beta Eta chapter at West Virginia University was formally initiated at Spring Conclave in St. Louis, Missouri.

The name "Sigma Theta Epsilon" finds its roots in the Greek words, "Sunergoi Theou Esman", meaning "Fellow Workers with God".